Reproductive Health And diseases in Human being Notes for NEET



Reproductive health literally means healthy reproductive organs with normal function. According to world health organization (W.H.O), reproductive health means a total well being m physical, emotional, behavioral and social aspects of reproduction A reproductive healthy person i8 one who has physically and functionally normal reproductive organs and normal behavioral and emotional interactions with other persons in all sex related aspects.

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PROBLEMS AND STRATEGIES REGARDING REPRODUCTIVE HEALTH


Rapidly expanding human populations, particularly in the developing countries like India and China, have greater proportions of young individuals who determine the size, health and prosperity of the future population. The Government of India initiated a number of programmes. its national level to attain total reproductive health as asOC1algoal.Atpresent,muchmore improved programme and reproduction related areas are in operation These are popularly termed as reproductive and child health care (RCH) programmes. the main aim of such programmes is 1o create awareness on people about reproductive organs, accessory organs of reproduction, secondary sexual characters, adolescence and associated changes, safe and hygienic sexual practices, sexually transmitted diseases (STDs), etc. And providing activities and support for building up of reproductively healthy society Few programmes undertaken by the government in this connection include massive child immunization, statutory an o-amniocentesis to legally check increasing female foeticide and maternity and child health and family


MATERNAL AND CHILD HEALTH (MCH) SERVICES AND FAMILY PLANNING


Maternity and child health services and family planning is one of the important programmes of health care centres. Under this programmes, health care centres carry out the following activities: It gives necessary information, guidance and help to the mothers before and after delivery so that they may properly look after themselves and the infants It ensures safe delivery of infant and postnatal care.

It organizes immunization programmes and arranges milk feeding programmes It trains the midwives also, to safely handle the delivery of infants. It educates the newly wedded couples about the importance of a small family and guides and helps them in having a small family.

In May, 1974 W.H.O launched a programme to immunize the children of the entire world against six communicable diseases: diphtheria, pertussis, tetanus, polio, tuberculosis and measles. 1he universal immunization programme for India was launched in 1985.


POPULATION EXPLOSION


At present, the human population is increasing at a rate of Over 2 persons every second or about 2,00,000 people every day or 8 million people every month. The world population which was around 2 billion (2000 million) in 1900 rocketed to about 6 billions by 2000. A similar trend was observed in India too. Our population, which was approximately 350 million at the time of our independence, reached close to the billion mark by 2000 and crossed the billion in May 2000. That means, every sixth person in the world is an Indian. This rapid increase in population over a relatively short period is called population explosion. The various reasons for population explosion are: Increase in longevity due to decline in death rate, Maternal Mortality Rate (MMR) and Infant mortality rate.Control of diseases has reduced the death rate and increased the average human age.better public health care, improvements in medical facilities and greater medical attention are playing crucial role in decreasing death rate and increasing birth rate. Advancement in agriculture, improvement in food storage conditions and better means of transport are causing rapid increase of human population Protection from natural calamities has decreased death rate.Certain religions are against family planning. Reduction in birth rate is the only practicable and direct method to control the population. It can be done in various ways.People particularly those in the reproductive age group, should be educated about the advantage of small family Posters showing a happy couple with two children with a slogan Hum Do Humare Do should be displayed. At present the marriageable age is 18 years for girls and 21 years for boys. By increasing the age of marriage population growth can be checked. Couples with small families can be encouraged by giving incentives. There are many birth control measures which can check birth rate such as, family planning, use of contraceptives,medical termination of pregnancies, etc


BIRTH CONTROL


The regulation of conception by preventive methods or devices to limit the number of offspring is called birth control. A variety of methods are known for birth control. The birth control methods which deliberately prevent fertilization are referred to as contraception These methods act by blocking one of the three major steps in the reproductive processes By blocking sperm transport to the ovum, blocking ovulation and by blocking implantation of early embryo.

The various birth control methods can be grouped into following three types

(i) Temporary methods (ii) Permanent methods

(ii) Medical termination of pregnancy.


Temporary methods

Temporary methods are further of many types, such as natural methods, barrier methods, oral contraceptives ,other contraceptives and abstinence. Natural methods avoid the meeting of sperm and ovum. These include safe period, coitus interruptus and lactational amenorrhoea. Safe period or rhythm method is also termed periodic or temporary abstinence because 1t requires refraining from sexual intercourse when conception is most likely, i.e., a few days before and a few days after ovulation. Coitus interruptus or withdrawal method involves withdrawal of the penis from the vagina by the male before ejaculation so that Semen is not deposited in the vagina and there is no fertilization. Lactational amenorrhoea method (absence of menstruation) is based on the fact that ovulation and therefore the menstrual cycle do not occur during the period of intense lactation following childbirth (parturition) This method is considered effective only upto a maximum period of six months following parturition and has no side effects In barrier methods ovum and sperms do not meet due to barriers so that fertilization does not occur. It includes chemical means (spermicides) and mechanical means (condoms, diaphragm, cervical cap, vault and intrauterine devices).

Condoms are made of thin rubber/ latex sheath used to cover the penis in the male or vagina and cervix in the female just before coitus so that the ejaculated semen is not released in the female reproductive tract and bence prevent fertilization. It is given free also by the government under the trade name Nirodh. Diaphragms, cervical caps and vaults are also made of rubber, inserted into the female reproductive tract to cover the cervix before coitus. 1hey prevent conception by blocking the entry of sperm through the cervix. They are reusable Intrauterine devices (aUDs) are plastic or metal objects which are inserted by doctors in the uterus through vagina. These are available as non-medicated IUDs (ie., Lippes loop), copper releasing IUDs (CuT, Cu7, multiload 375) and hormone releasing fUDs (progestasert, LNG-20) UDs increase phagocytosis of sperms within the uteru and the Cu ions released by some suppress sperms

motility and fertilizing capacity. The hormone releasing IUDs make the uterus unsuitable for implantation and the cervix hostile to the sperms. Oral contraceptives are physiological contraceptive devices These are used in the form of tablets, therefore, they are called pills. Pills have to be taken for 21 days starting within the first five days of the menstrual cycle. After a gap of seven days it has to be repeated. Pills are very effective with lesser side effects Hormonal pills act in the following four ways By inhibiting the ovulation.

By inhibiting the motility and secretory activity of Ovucs.By changing the cervical mucus and impair its ability to allow passage and transport of sperm, By alteration in uterine endometrium to make it unsuitable for implantation Oral contraceptive pills contain entner progesterone alone

or a combination of progesterone and estrogen, These are of two types combined pills and mini pills. Combined pills are most commonly used contraceptive pills which contain synthetic progesterone and estrogen

to check ovulation. Mini pills contain progestin only Pills Mala D and Mala N are commonly used combined contraceptive pills. these are taken daily without break Sahelt, a new oral contraceptive pill for female has been developed at Central Drug Research institute (CDR), Lucknow It contains a nonsteroidal preparation called centehroman which is taken once in a week after an initial intake of twice a week dose for three months. It has very high contraceptive vahie with very little side effects Other contraceptives include implants, hormone oh Inherit ajections, etc.

The most common form of emergency contraceptive isakit consisting of a high dose of birth control pills. These kitsCan prevent pregnancy within 72 hours after unprotected Sexual mtercourse


Permanent method

Permanent method or surgical method involves sterilization which provides a permanent and sure birth control. Sterilization in male is called vasectomy and in females it is called tubectomy. Vasectomy is a very simple surgical method involving the cutting of the vas deferens in man. The vas deferens is cut and then both ends are folded and tied so that the sperm from the testicles cannot move out. Tubectomy involves the blocking of the Fallopian tubes. The Fallopian tubes are tied twice and cut between the knots. In the latest methods the Fallopian tubes are folded and ringed by synthetic rings with the help of an instrument called laparoscopy.

No doubt, the widespread use of these methods have a significant role in checking uncontrolled growth of population. However, their nausea, abdominal pain, breakthrough bleeding, irregular menstrual bleeding or even breast cancer, significant, should not be totally ignored.


Medical termination of pregnancy

Medical termination of pregnancy (MTP) or Induced abortion is intentional or voluntary termination of pregnancy before the foetus becomes viable. It is one of the most widely used methods of fertility control in the world. MTP comparatively safe upto 12 weeks (the first trimester) of pregnancy, It becomes a risky affair in first trimester period of pregnancy as the foetus becomes intimately associated with the maternal tissues Government of India legalised MTP in 1971. At present termination is legally allowed upto 28th week of pregnancy 1f the family physician and the gynaecologist  consider the need for abortion. MTPs plays a significant role in decreasing the human population but nowadays it is being misused to abort even the normal female foetuses.


SEXUALLY TRANSMITTED DISEASES (STDs)


Diseases or infections which are transmitted throughsexual intercourse with infected persons are collectivelycalled sexually transmitted diseases (STDs) or venereal diseases (VD) or reproductive tract infections (RTD.Gonorrhoea, syphilis, genital herpes, chlamydiasis.genital warts, trichomoniasis, hepatitis-B and of course,the most discussed infection in the recent years, HIVleading to AIDS are some of the common STDs. ExceptHIV infection, hepatitis B and genitalherpes all otherProperly.s are usually caused by bacteria, viruses.protozoans,nematodes, ectoparasites and fungi proper and timely treatment is not given it may lead to duplications such as pelvic inflammatory diseases (PID) tons, stillbirths, ectopic pregnancies, infertility or Ven cancer of reproductive tract

Syphilis:It is caused bacterium Treponema pallidum Symptoms of th1s disease are painless ulcer or chancre on the genitals, swelling of local lymph glands, skin lesions,rashes, hair loss, swollen jonts.It is transmitted through sexual contact and from mother to children.

Gonorrhoea : Gonorrhoea is caused by bacterium Neisseria gonorrhoeae The bacterium lives in genital tubes, produces pus containing discharge, pain around genitals and burning sensation during urination. It may lead to arthritis and eye infection in children of gonorrhoea afflicted

mothers.It is spread through sexual contact, common toilets

and under-clothes.

AIDS: AIDS is caused by human immunodeficiency virus (HIV).The symptoms of AIDS include fever, lethargy, pharyngitis, weight loss, nausea, headache, rashes, etc. HIV is transmitted via semen and blood.

Hepatitis B:lt is cauSed by hepatitis B virus (HBV). lts symptoms include fatigue. jaundice, persistent low grade fever, rash and abdominal pain. It can cause cirrhoSis and possibly liver cancer. It is the most infectious disease. Mode of transmission may be blood transfusion, sexual contact, saliva, tears, intravenous drug abuse, tattooing, ear and nose piercing, sharing of razors, etc.

Genital herpes: Genital herpes is caused by herpes simplex virus. Vesiculopustular lesions followed by clusters of painful erythematous ulcers over external genitalia and perianal regions, vaginal and urethral discharge and swelling of lymph nodes are some common symptoms of the disease. The disease is primarily transmitted through genital secretions but also contact with genitalia

Genital warts: Genital warts are caused by human papillomavirus. Symptoms include benign, hard outgrowths with horny surface (warts) over the skin and mucosal surface of external genitalia and perianal area.It spreads through sexual intercourse with carriers of the viruses of this disease.

Chlamydiasis: Chlamydiasis is caused by Chlamydia trachomatis of DEFGHIJK serotypes. Chlamydia is an obligate intracellular pathogen. It causes urethritis, epididymitis, mucopurulent, cervicitis, inflammation of Fallopian tubes, proctitis (rectal pain with mucus and occasional bleeding), etc. It spreads by sexual contact with infected mating partner

Trichomoniasis: trichomoniasis is caused by Trichomana vaginais The parasite affects both males and females

In females it causes vaginitis with foul smelling, yellow vaginal discharge and burning sensation. In males 1t Causes urethritis, epididymitis and prostatitis resulting in pain and burning sensation It is transmitted through sexual intercourse. STDs are a major threat to a healthy society. Therefore, prevention or early detection and cure of these diseases are given prime consideration under the reproductive health care programmes. Though all persons are vulnerable to these infections, their incidences are reported to be very high among persons in the age group of 15-24 years. Following precautions should be taken

-  Avoid sex with unknown partners/multiple partners

-  Always use condoms during coitus.

-  In case of doubt a qualified doctor should be consulted for early detection and complete treatment if diagnosed with disease.


INFERTILITY

Inability to conceive or produce children in spite of unprotected sexual cohabitation is called infertility. It is caused by various reasons which can be grouped under physical, congenital, immunological or even psychological disorders. Specialized infertility clinics can help in the diagnosis and proper treatment of some of these disorders and enable these couples have children. However, where such diagnosis and treatment are possible, the couples can be assisted to have children through certain special techniques called assisted reproductive technologies (ART) Assisted reproductive technologies (ART Assisted reproductive technologies (ART) include a number of special techniques which assist infertile couples to have children. Some important techniques of ART are

(i) Test tube baby programme

(ii) Artificial insemination technique (AlT)

(iii) Gamete intra Fallopian transfer (GIFT)

(iv) Intracytoplasmic sperm injection (ICSI).


Test tube baby programme

The baby produced by conceiving in a culture dish and nursing in the uterus is called a test tube baby This method involves in vitro fertilization (IVF), i.e fertilization of male and female gamete outside the body in almost similar conditions as that in the body followed by embryo transfer (ET) Embryo upto 8 blastomeres is transferred into the fallopian tube (ZIFT Zygote Intra Fallopian Transfer) to complete its further development.

If the embryo is with more than 8 blastomeres, it is transferred into the uterus (1UT-IntraUterine Transfer) to complete its further development, A developing embryo can be inserted in the uterus of another female. A woman who substitutes or takes the place of the real mother to nurse the embryo is called surrogate mother or genetic mother.

Artificial insemination technique (AIT)

This technique is used in those females where the husband is either unable to inseminate the female or has very low sperm counts in the ejaculation In this technique the semen collected either from the husband or a healthy donor is artificially introduced into the vagina or into the uterus (IUL- intrauterine insemination) of the femałe.

Gamete intra Fallopian transfer (GIFT)

This method is used in females who cannot produce ova but can provide a suitable environment for fertilization and further development of embryo in the oviducts. In this technique, ovum from the donor female is surgically removed and then introduced into the Fallopian tube of females incapable of producing ovum for fertilization.

Intra cytoplasmic sperm injection (ICSI)

This technique sperm is directly injected into the ovum to form an embryo in the laboratory. The embryo 1s transferred by ZIFT or IUT in women.



DETECTION OF FOETAL DISORDERS DURING EARLY PREGNANCY


Foetal disorders during early pregnancy can be detected by following techniques cted

- amniocentesis

-  chorionic villi sampling (CVS)

-  non-invasive techniques

-  foetoscopy.


Amniocentesis

Transabdominal aspiration of fluid from the amniotic sac of the foetus is called amniocentesis. It is a foctal sex deternmination and disorder test based on the chromosomal pattern in the amniotic fluid surrounding the developng embryo.At the early stage of pregnancy (14th or 15th week), the location of the foetus and placenta is determined by sonography.Then a small amount of amniotic fluid is drawn by passing a special surgical syringe needle into the abdominal wall and uterine wall into the amniotic sac containing amniotic fluid.The amniotic fluid contains cells from foetus skin a respiratory tract

These cells are cultured and are used to determine chromosomal abnormalities (Down's syndrome, klinefelter's syndrome, ete.) and metabolic disorder phenylketonuria, sickle cell anaemia etc)  foetus. Unfortunately, this useful technique is killing the normal female foetuses. It has been legally banned 1or the determination of sex to avoid female foeticide.


Chorionic villi sampling

In chorionic villi sampling (CVS) technique the physician inserts a narrow, flexible tube through the mother 's vagina and cervix into the uterus and withdraws a small amount of foetal tissue (chorionic villi) from the placenta.


Non-invasive technique

One of the widely used non-invasive techniques to determine foetal condition is ultrasound imaging. Another technique is based on the fact that a few foetal blood cells leak across the placenta into the mother's blood stream. A blood sample from the mother provides enough foetal cells that can be tested for genetic disorders.


Foetoscopy 

Fetoscopy is another technique in which a needle thin tube containing a viewing scope is inserted into the uterus,

giving the physician a direct view of the foetus.

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